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Principles of Tissue Engineering is the definitive resource in the field of tissue engineering. The fourth edition offers an update on this rapidly progressing field, combining prerequisites for a general understanding of tissue growth and development, tools and theoretical information needed to design tissues and organs and a presentation by experts of what is currently known about each specific organ system. As in previous editions, this book is a comprehensive work that strikes a balance among the diversity of subjects related to tissue engineering, including biology, chemistry, material science, and engineering, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies.  This up-to-date coverage of stem cell biology and other emerging technologies -such as brain-machine interfaces for controlling bionics and neuroprostheses  is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike.

Principles of Tissue Engineering

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PRINCIPLES OF TISSUE ENGINEERING 4

Duration

Duration Unit Of Measure

Transaction Type

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Contents.
Foreword.
Preface.
Preface to the Third Edition.
Preface to the Second Edition.
Preface to the First Edition.
List of Contributors.
1: Introduction to Tissue Engineering.
2: The History and Scope of Tissue Engineering.
3: The Challenge of Imitating Nature.
4: From Mathematical Models to Clinical Reality.
5: Stem Cells as Building Blocks.
6: Moving into the Clinic.
7: Tissue Engineering: Future Perspectives.
8: The Basis of Growth and Differentiation.
9: Molecular Biology of the Cell.
10: Molecular Organization of Cells.
11: The Dynamics of Cell-ECM Interactions, with Implications for Tissue Engineering.
12: Matrix Molecules and Their Ligands.
13: Morphogenesis and Tissue Engineering.
14: Gene Expression, Cell Determination, and Differentiation.
15: In Vitro Control of Tissue Development.
16: Engineering Functional Tissues: In Vitro Culture Parameters.
17: Principles of Bioreactor Design for Tissue Engineering.
18: Regulation of Cell Behavior by Extracellular Proteins.
19: Growth Factors.
20: Mechanobiology, Tissue Development and Organ Engineering.
21: In Vivo Synthesis of Tissues and Organs.
22: In Vivo Synthesis of Tissues and Organs.
23: Biomaterials in Tissue Engineering.
24: Micro-Scale Patterning of Cells and their Environment.
25: Cell Interactions with Polymers.
26: Matrix Effects.
27: Polymer Scaffold Fabrication.
28: Biodegradable Polymers.
29: 3D Scaffolds.
30: Transplantation of Engineered Cells and Tissues.
31: The Role of the Host Immune Response in Tissue Engineering and Regenerative Medicine.
32: Tissue Engineering and Transplantation in the Fetus.
33: Immunomodulation.
34: Challenges in the Development of Immunoisolation Devices.
35: Stem Cells.
36: Embryonic Stem Cells.
37: Induced Pluripotent Stem Cells.
38: Stem Cells in Tissue Engineering.
39: Embryonic Stem Cells as a Cell Source for Tissue Engineering.
40: Postnatal Stem Cells in Tissue Engineering.
41: Gene Therapy.
42: Gene Therapy.
43: Gene Delivery into Cells and Tissues.
44: Breast.
45: Breast Tissue Engineering: Reconstruction Implants and Three-Dimensional Tissue Test Systems.
46: Cardiovascular System.
47: Progenitor Cells and Cardiac Homeostasis and Regeneration.
48: Cardiac Tissue Engineering.
49: Blood Vessels.
50: Tissue-Engineering Heart Valves.
51: Endocrinology and Metabolism.
52: Generation of Pancreatic Islets from Stem Cells.
53: Bioartificial Pancreas.
54: Thymus and Parathyroid Organogenesis.
55: Gastrointestinal System.
56: Stem Cells in the Gastrointestinal Tract.
57: Liver Stem Cells.
58: Hepatic Tissue Engineering.
59: Hematopoietic System.
60: Hematopoietic Stem Cells.
61: Blood Components from Pluripotent Stem Cells.
62: Red Blood Cell Substitutes.
63: Lymphoid Cells.
64: Kidney and Genitourinary System.
65: Stem Cells in Kidney Development and Regeneration.
66: Renal Replacement Devices.
67: Genitourinary System.
68: Musculoskeletal System.
69: Mesenchymal Stem Cells in Musculoskeletal Tissue Engineering.
70: Bone Regeneration.
71: Tissue Engineering for Regeneration and Replacement of the Intervertebral Disc.
72: Articular Cartilage Injury.
73: Engineering Cartilage and Other Structural Tissues: Principles of Bone and Cartilage Reconstruction.
74: Tendons and Ligament Tissue Engineering.
75: Skeletal Tissue Engineering.
76: Nervous System.
77: The Nervous System.
78: Brain Implants.
79: Brain-Machine Interfaces.
80: Spinal Cord.
81: Protection and Repair of Hearing.
82: Ophthalmic.
83: Stem Cells in the Eye.
84: Corneal Replacement Tissue.
85: Retinal Degeneration.
86: Vision Enhancement Systems.
87: Oral/Dental Applications.
88: Biological Tooth Replacement and Repair.
89: Tissue Engineering in Oral and Maxillofacial Surgery.
90: Periodontal Tissue Engineering.
91: Respiratory System.
92: Tissue Engineering for the Respiratory Epithelium: Cell-Based Therapies for Treatment of Lung Disease.
93: Lungs.
94: Skin.
95: Cutaneous Epithelial Stem Cells.
96: Wound Repair: Basic Biology to Tissue Engineering.
97: Bioengineered Skin Constructs.
98: Tissue-Engineered Food.
99: Principles of Tissue Engineering for Food.
100: Prospects for In Vitro Cultured Meat &#x2013; A Future Harvest.
101: Clinical Experience.
102: Current State of Clinical Application.
103: Tissue-Engineered Skin Products.
104: Tissue-Engineered Cartilage Products: Clinical Experience.
105: Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopedic and Craniofacial Surgery.
106: Tissue-Engineered Cardiovascular Products.
107: Tissue-Engineered Organs.
108: Regulation, Commercialization and Ethics.
109: The Regulatory Process from Concept to Market.
110: Business Issues.
111: Ethical Issues.
Epilogue.
Index.

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Principles of Tissue Engineering