Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the\xa0second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.
Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Contents.
Preface.
1: Discovery of Small-Molecule Ras Inhibitors that Display Antitumor Activity by Interfering with Ras·GTP–Effector Interaction.
2: An Orthosteric Inhibitor of the RAS–SOS Interaction.
3: Conformation-Specific Inhibitors of Raf Kinases.
4: Inhibitors of the ERK Mitogen-Activated Protein Kinase Cascade for Targeting RAS Mutant Cancers.
5: Inhibiting the RAS–PI3K Pathway in Cancer Therapy.
6: The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers.
7: p21-Activated Kinase Inhibitors.
8: Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Toward Inhibiting K-Ras and N-Ras Functions.
9: Synthetic Lethal Genetic Screens in Ras Mutant Cancers.
