Cancer Metastasis: Biologic Basis And Therapeutics

Publisher Cambridge University Press

Format

eBook

2nd Edition 1st Edition

Quantity

Add New

Publisher

Cambridge University Press

Volume

Copyright

2011

ISBN13

9781139136204

Release

Format

eBook

Grade Level

College Freshman - College Senior

DDC
TBD

Overview

Comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease.
Front Cover.
Cancer Metastasis.
Title Page.
Copyright Page.
Dedication.
Contents.
Contributors.
Overview: Biology Is the Foundation of Therapy.
1: Basic Research.
2: Introduction to Basic Research.
3: Models and Tools for Metastasis Studies.
4: Animal Models of Cancer Metastasis.
5: Drosophila and Zebrafish: Genetic Models for Cancer Metastasis.
6: Computational Models.
7: Intravital Microscopy to Visualize Invasion and Metastasis.
8: Genes.
9: Metastasis-Promoting Genes.
10: The Role of Metastasis Suppressor Genes in Metastasis.
11: Stromal-Derived Factors That Dictate Organ-Specific Metastasis.
12: Metastasis Genes: Epigenetics.
13: Germline Variation and Other Host Determinants of Metastatic Potential.
14: The Influence of Aging and Cellular Senescence on Metastasis.
15: Various Properties of Cancer Cells.
16: The Continuum of Epithelial Mesenchymal Transition – Implication of Hybrid States for Migration and Survival in Development and Cancer.
17: Apoptosis, Anoikis, and Senescence.
18: Metastatic Inefficiency and Tumor Dormancy.
19: Stromal Cells/Extracellular Matrix.
20: Role of Inflammation in Metastatic Progression.
21: Proteolytic Cascades in Invasion and Metastasis.
22: Role of Matrix Metalloproteinases in Tumor Invasion and Metastasis.
23: Cell-Derived Microvesicles and Metastasis.
24: Systemic Factors.
25: Exploring the Earliest Steps in Metastasis: The Pre-Metastatic Niche.
26: Growth Regulatory Pathways Contributing to Organ Selectivity of Metastasis.
27: Determinants of Organ-Specific Metastasis.
28: Function and Expression of the uPA/uPAR System in Cancer Metastasis.
29: The Lymphatics: On the Route to Cancer Metastasis.
30: Clinical Reseaech.
31: Introduction to Clinical Research.
32: Sarcoma.
33: Neuroblastoma.
34: Retinoblastoma.
35: Primary Brain Tumors and Cerebral Metastases.
36: Head and Neck Cancer Metastasis.
37: Cutaneous Melanoma: Therapeutic Approaches for Metastatic Disease.
38: Gastric
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Cancer Metastasis: Biologic Basis And Therapeutics

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