This volume is being published at a critical time in U.S. history and serves as a comprehensive and much-needed update to what is known about Latinx health. As both the U.S. and Latinx subgroups experience demographic shifts, it is critical to examine the current epidemiology of Latinx health, as well as the factors influencing the health and well-being of this growing population. Chapters written by highly respected experts illuminate the diversity of the Latinx population and provide strategies to mitigate many of the challenges they face, such as migrating to new destinations. The book is designed to enrich dialogue around the multilevel determinants of Latinx health and concludes with a call to action for increased culturally congruent, theoretically informed and participatory Latinx health research. The book also encourages the mentorship and growth of early career and junior investigators to conduct research on Latinx health issues. Chapters include: Chronic disease and mental health issues in Latinx populations; Substance use among Latinx adolescents in the United States; Physical and intellectual and developmental disabilities in Latinx populations; Health insurance reform and the Latinx population; Immigration enforcement policies and Latinx health; Research priorities for Latinx sexual and gender minorities; Racial and ethnic discrimination, intersectionality, acculturation, and Latinx health. This invaluable compendium provides a foundation of understanding Latinx health and well-being and guides future research and practice. It is essential for researchers, practitioners, and students of public health and social sciences including community and health psychology, health administration and policy, community health education, medical anthropology, medical sociology, population health, and preventive medicine. Also for federal, state, and local agencies, including health departments, and other Latinx- and immigrant-serving community organizations.