Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Publisher Springer

Format

eBook

2nd Edition 1st Edition

Quantity

Add New

Publisher

Springer

Volume

Copyright

2013

ISBN13

9783642407178

Release

Format

eBook

Grade Level

College Freshman - College Senior

DDC
TBD

Overview

Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes.\xa0In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions.\xa0This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.
Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Dedication Page.
Preface.
Acknowledgments.
Contents.
Contributors.
1: Introduction and Scientific Principles.
2: From Hemoglobin Based Oxygen Carrier to Oxygen Therapeutics, Blood Substitutes, Nanomedicine and Artificial Cells.
3: From the Atmosphere to the Mitochondrion: The Oxygen Cascade.
4: Biochemistry of Hemoglobin.
5: The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity.
6: Hemorrhagic Shock and Current Treatments.
7: Pathophysiology of Hemorrhagic Shock and Resuscitation.
8: Allogeneic Blood Transfusion for Surgical and Traumatic Hemorrhage.
9: Pre-Hospital Fluid Resuscitation in Civilian and Military Populations.
10: Current Issues of HBOCs and Regulatory Framework.
11: NIH/FDA/DOD Interagency Working Group on Oxygen Therapeutics.
12: Regulatory Framework for Hemoglobin-Based Oxygen Carrier Trials.
13: Approaches to HBOCs.
14: HBOCs from Chemical Modification of Hb.
15: Design of Nonhypertensive Conjugated Hemoglobins as Novel Resuscitation Fluids.
16: Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure.
17: Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock.
18: Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application.
19: Zero-Link Hemoglobin (Oxyvita®): Impact of Molecular Design Characteristics on Pre-Clinical Studies.
20: Polynitroxylated Pegylated Hemoglobin (PNPH): A Nanomedicine for Critical Care and Transfusion.
21: ATP-Adenosine-GSH Crosslinked Hb, An Oxygen Carrier with Pharmacological Properties for Multiple Therapeutic Indications.
22: Albumin-Heme Oxygen Carriers.
23: Recombinant Human Hb-SOD Fusion Proteins.
24: In-Vitro Production of Functional RBCs from Hematopoietic Stem Cells.
25: Potential Applications of HBOCs.
26: Liposome-Encapsulated Hemoglobin: Potential Cli
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Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

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