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ANTIBODY FC: LINKING ADAPTIVE AND INNATE IMMUNITY

Medical Science & Research

Health, Medicine & Nursing

Gt Product Group

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B2B GT

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B2B & B2C

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

Antibody Fc

POST SECONDARY FOUR YEAR

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COLSR

Duration

Duration Unit Of Measure

Transaction Type

Front Cover.
Halftitle Page.
Title Page.
Copyright page.
Short Contents.
Contents.
List of Contributors.
1: Effector Mechanisms.
2: Antibody-Dependent Cellular Cytotoxicity (ADCC).
3: Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control.
4: Interactions between the Complement System and Fc&#x03B3; Receptors.
5: Effector Cells.
6: Natural Killer Cells.
7: Phagocytes and Immunoglobulins.
8: B Cells.
9: FcR.
10: Structural Recognition of Immunoglobulins by Fc&#x03B3; Receptors.
11: Fc&#x03B3;Rs across Species.
12: Variability of the Fc Domain.
13: Human IgG Subclasses.
14: Antibody Glycosylation.
15: Genetic Associations.
16: Activating and Inhibitory Fc&#x03B3;Rs in Autoimmune Disorders.
17: Fc&#x03B3; Receptor Polymorphisms and Susceptibility to Infection.
18: Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer.
19: Evolving Areas.
20: No Mechanism Is an Island.
21: Fc Receptor-Dependent Immunity.
22: Fc&#x03B3; Receptors as Therapeutic Targets.
23: Fc Protein Engineering.
24: Bacterial Modulation of Fc Effector Functions.
25: Pathogenic Exploitation of Fc Activity.
26: Mechanisms of Immunoglobulin-Mediated Mucus Entrapment of Pathogens at Various Mucosal Surfaces.
Index.

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Antibody Fc