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SBAST: GIGASEAL FORMATION IN PATCH CLAMPING

Engineering

Mathematics & Science

Gt Product Group

Binding Format

Marketing Imprint Name

B2B GT

CL Carton Count

Imprint Name

B2B & B2C

This book presents an investigation of gigaseal formation using micro/nanotechnology. The aims of the book are twofold. First, it explains the mechanisms of gigaseal formation using the latest discoveries. Second, it provides practical techniques for frequent formation of high resistance seals. The formation of a high-resistance electrical seal, also known as a gigaseal, between a cell membrane and a glass micropipette tip is essential in patch-clamp experiments. Even though four decades have passed since the introduction of the patch-clamping technique by Neher and Sakmann, gigaseal formation remains an obstacle in developing the high-throughput ion channel screening systems required by the pharmaceutical industry. Here the authors share their latest methods for achieving gigaseal formation and describe techniques that are highly desirable at both research and industrial levels. Nanotechnology has been found to be a powerful tool for studying and modifying glass micropipettes and in tackling the problem of gigaseal formation.

Gigaseal Formation in Patch Clamping

POST SECONDARY FOUR YEAR

COLFR

COLJR

COLSO

COLSR

Duration

Duration Unit Of Measure

Transaction Type

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Preface.
Contents.
Abbreviations.
Introduction.
1: Development of Patch Clamping.
2: Gigaseal Formation.
3: Effect of Roughness on Gigaseal Formation.
4: Effect of Hydrophilicity on Gigaseal Formation.
5: Effect of Tip Size on Gigaseal Formation.
6: Study of Glass Micropipettes from Tip Formation to Characterization.

Gigaseal Formation in Patch Clamping.css-1p8rvzy{position:absolute;padding-left:8px;}

Gigaseal Formation in Patch Clamping