The Greenspans are the envy of Brookline, Massachusetts. Scott Greenspan is a successful physician with his own cardiology practice. His wife, Deb, spends her free time helping resettle refugees. Their daughter, Maya, works at a distinguished New York publishing house and their son, Gideon, is preparing to follow in his father's footsteps. But when Scott is caught falsifying blood samples at work, he sets in motion a series of scandals that threatens to shatter his family. Deb leaves him for a female power broker; Maya rekindles a hazardous affair from her youth; and Gideon drops out of college to go on a dangerous journey that will put his principles to the test.