This book provides a comprehensive analysis of fundamental topics related to blockchain. Throughout, the authors explore different vital issues and specific areas of blockchain. For convenience, the authors present the elementary description, visualize the working procedure of blockchain paradigm, and highlight the areas it can be applied in real life. They explain the blockchain process from a diverse perspective i.e. distributed Internet of Things (IoT), interdependent networks, intelligent mining, etc. They also analyze the interconnection of a blockchain network and such novel research areas to show a pathway towards a new research direction. This book also holds the core challenges and open research issues of blockchain technology, considering existing applications. Chapters include consensus mechanisms of blockchain, blockchain applicability in centralized and decentralized internet of things, blockchain interoperability from the perspective of interdependent networks, and blockchain for resource-constrained devices. Specifies the importance of theoretical methods in dealing with problems in the context of blockchain for interdependent decision making; provides a comprehensive investigation of blockchain algorithms and the recently developed methods based on this algorithm; provides basics and mathematical foundations needed to learn and deploy blockchain.